AI Antibody Humanization Platform

Your Trusted Partner in Antibody Humanization: Accelerate Your Drug Discovery Process!

Are you currently facing long antibody development cycles, the risk of immunogenicity, or challenges in preserving antibody efficacy during humanization? Creative Biolabs' cutting-edge AI Antibody Humanization Platform helps you accelerate the development of high-quality, low-immunogenic therapeutic antibodies. Through our advanced AI algorithms and seamless integration with our wet lab facilities, we enable the rational design of clinical-ready antibodies, significantly shortening your path from discovery to the clinic.

How Creative Biolabs' AI Antibody Humanization Platform Can Assist Your Project?

Our AI Antibody Humanization Platform provides a complete, end-to-end solution for transforming animal-derived antibodies into human-like therapeutic candidates. We deliver highly specific, high-affinity antibodies with reduced immunogenicity risk, a critical factor for successful clinical development.

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Workflow

Why Choose Creative Biolabs?

• Intelligent Closed Loop of AI and Wet Labs: Our core strength lies in the seamless, intelligent integration of AI with our wet lab facilities. All AI-driven stages are validated through rigorous experimental workflows, and the resulting data is fed back into our models. This creates a continuous learning loop that constantly improves the predictive accuracy and precision of our AI models.
• End-to-End Continuous Process: We offer a fully integrated service that spans from initial discovery and humanization to final engineering and validation. This streamlined, end-to-end process drastically shortens R&D cycles and simplifies project management for our clients.
• Predictive Accuracy and Efficiency: By combining AI's powerful data analysis and predictive capabilities with our deep biological expertise, we dramatically improve the success rate and speed of antibody development. Published data have demonstrated that our approach can successfully humanize antibodies that were challenging to optimize with traditional methods. For example, our platform has successfully restored the affinity of an antibody by identifying and preserving a key framework residue that would have been overlooked by simple CDR grafting.
• Data-Driven Rational Design: We move beyond traditional trial-and-error methods. Our decisions are based on the robust analysis of structural data, sequence homology, and humanness scores, ensuring a rational and predictable design process.
• Proficiency and Background: Our team consists of specialists possessing in-depth knowledge and extensive experience in artificial intelligence, structural biology, and drug discovery. This interdisciplinary expertise allows us to tackle the most complex humanization challenges with confidence.
• Tailored Solutions and Adaptability: We recognize that each project possesses distinct characteristics. Our platform and services are highly customizable and can be tailored to meet your specific project needs and objectives.

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Introduction to AI Antibody Humanization

Antibody-based therapies have transformed medicine, but early generations, often derived from non-human sources like mice, frequently caused severe immune responses. Antibody humanization, which involves genetically modifying these antibodies to resemble human ones, reduces immunogenicity and enhances therapeutic potential. Traditional techniques, such as CDR grafting, often struggle with losing binding affinity due to critical antigen-binding sites extending beyond the CDRs. AI and computational biology have revolutionized this process by utilizing sophisticated algorithms to predict protein structures and model antigen-antibody interactions, enabling more precise and rational humanization. This approach minimizes functional loss while optimizing humanization, leading to safer, more effective therapies.

Fig.1 Schematic diagram of AI-based antibody developability.¹

Platform Technology & Infrastructure

• Proprietary AI engine
• Comprehensive database
• State-of-the-art wet lab facilities
• High-throughput screening
• Sequencing
• Antibody characterization

Creative Biolabs' AI Antibody Humanization Platform marks a transformative advancement in therapeutic antibody development, merging artificial intelligence with stringent wet lab validation to deliver high-quality, clinical-ready antibodies with unmatched speed and precision. This innovative, data-driven approach accelerates drug discovery, supporting the creation of safer, more effective therapies. For those looking to expedite their antibody programs, our team is ready to offer tailored solutions to meet unique project needs. Contact us today to explore how our platform can enhance your antibody development process.

Reference

1. Santuari, Luca, et al. "AI-accelerated therapeutic antibody development: practical insights." Frontiers in Drug Discovery 4 (2024): 1447867. DOI: 10.3389/fddsv.2024.1447867. Distributed under an Open Access license CC BY 4.0, without modification.