AI-Driven Protein Degrader Discovery Service

Are you currently facing long drug development cycles, difficulty in identifying novel therapeutic targets, or challenges in optimizing lead compounds for complex diseases? Our AI-Driven Protein Degraders Discovery service helps you accelerate drug discovery and obtain highly potent and selective protein degraders through advanced artificial intelligence and high-throughput screening platforms.

How Creative Biolabs' AI-Driven Protein Degraders Discovery Can Assist Your Project?

Creative Biolabs' AI-Powered Protein Degraders Discovery service offers an efficient approach for the identification, design, and optimization of novel protein degraders. This service tackles previously "undruggable" targets, thereby broadening the scope of therapeutic opportunities. We deliver comprehensive solutions, from initial target identification to lead compound optimization, significantly reducing the time and resources typically required in traditional drug discovery. Our strategy centers on harnessing the cell’s intrinsic protein degradation mechanisms to selectively target and eliminate proteins responsible for disease.

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Workflow

Why Choose Creative Biolabs?

• Cutting-Edge AI Platform: We leverage proprietary deep learning algorithms and vast datasets to predict and design novel protein degraders with unprecedented speed and accuracy. This significantly expands the druggable proteome by identifying targets previously considered intractable.
• Expertise in E2 Targeting: Beyond conventional E3 ligase approaches, Creative Biolabs possesses unique expertise in targeting ubiquitin conjugating enzyme (E2) pathways. This innovative strategy, supported by Published Data, offers potential for increased efficacy due to broader E2 expression and reduced risk of resistance, opening new avenues for therapeutic intervention.
• Integrated Wet Lab Validation: Our seamless integration of computational design with robust wet lab validation ensures that all predicted candidates are rigorously tested and confirmed for their degradation activity, selectivity, and mechanism of action. This end-to-end capability provides reliable and actionable data.
• Optimized Lead Generation: We focus on delivering highly optimized lead compounds with excellent drug-like properties, including orally available degraders with nanomolar potency, ready for seamless transition into preclinical studies.

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Introduction of AI-Driven Protein Degraders Discovery

Protein homeostasis, balancing synthesis, folding, and degradation, is vital for cellular function. Disruption in this balance links to numerous diseases, including cancer and neurodegeneration. Traditional drugs targeting active protein sites often fall short, especially for proteins lacking binding sites or requiring high doses. Targeted Protein Degradation (TPD) offers a transformative approach, engaging the ubiquitin-proteasome system to selectively degrade unwanted proteins. Techniques like PROTACs utilize ligands to direct proteins to E3 ligases for degradation. Novel TPD methods now target E2 enzymes, providing alternatives with potentially higher efficacy and lower resistance. Advanced AI and deep generative models facilitate TPD discovery by identifying novel targets and designing effective degraders, streamlining drug development.

Fig.1 Diagrammatic representation illustrating strategies for targeted protein degradation in neurodegeneration targets.¹

Frequently Asked Questions

Q1: How does Creative Biolabs' AI-driven approach differ from traditional protein degrader discovery methods?

A: Our AI-driven approach significantly accelerates the discovery process by leveraging advanced machine learning and deep generative models. This allows us to rapidly identify and design novel degrader candidates, including those targeting E2 enzymes, which are often overlooked by traditional methods. This efficiency translates into faster timelines and a higher success rate in identifying potent and selective compounds.

Q2: What types of proteins can be targeted using Creative Biolabs' AI-Driven Protein Degraders Discovery service?

A: Our platform is highly versatile and can target a wide range of proteins, including those previously considered "undruggable" due to the absence of traditional binding pockets. This includes proteins involved in various disease pathways across oncology, neurology, and other therapeutic areas. We encourage you to discuss your specific target with our team to explore its degradability potential.

Q3: What methods does Creative Biolabs employ to guarantee the selectivity and safety of the identified protein degraders?

A: Selectivity and safety are paramount. Our AI models are trained on extensive datasets to predict off-target interactions, and our rigorous wet lab validation includes comprehensive selectivity profiling against a broad panel of proteins. We employ multiple in vitro and cellular assays to confirm on-target degradation and assess preliminary toxicity, ensuring that the identified compounds exhibit high specificity and a favorable safety profile.

Q4: Can Creative Biolabs' service help with lead optimization for existing degrader candidates?

A: Absolutely! Our AI-driven platform is not only for de novo discovery but also highly effective for optimizing existing lead compounds. We can use our computational tools to predict modifications that enhance potency, selectivity, ADME properties, and overall drug-like characteristics, helping you refine your candidates for preclinical development.

Q5: What kind of data or information do I need to provide to start a project with Creative Biolabs?

A: To get started, we typically require information about your target protein (sequence, structure if available, biological context), the disease indication, and your specific project goals. The more detailed information you can provide, the more precisely we can tailor our AI models and experimental design to your needs.

Creative Biolabs' AI-Driven Protein Degraders Discovery service transforms drug development by merging sophisticated AI with deep biological expertise. This synergy enables clients to explore new therapeutic avenues, tackle previously elusive protein targets, and expedite the delivery of novel treatments. Our all-encompassing workflow—from design powered by AI to meticulous wet lab validation—ensures the production of highly potent, selective, and optimized protein degrader candidates. Contact us today to explore your project's potential.

Reference

1. Kuemper, Sandra et al. "Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?" Frontiers in Molecular Neuroscience vol. 17 1370509. 15 Apr. 2024, DOI:10.3389/fnmol.2024.1370509 Distributed under Open Access license CC BY 4.0, without modification.