Equipped with state-of-the-art artificial intelligence, big data, and machine learning, Creative Biolabs offers a wide variety of antibody engineering services to quickly and efficiently optimize the existing antibodies via artificial intelligence (AI) based algorithms, such as affinity, solubility, cross-reactivity, manufacturability, immunogenicity, specificity, stability.
Antibody engineering has been widely used to modify monoclonal antibody (mAb) sequences and/or structures to enhance or dampen their functionality to address the therapeutic needs. Conventional antibody engineering (i.e. humanization, isotype switching, chimerization) is usually performed by cloning and sequencing variable region cDNAs and grafting select regions onto a suitable framework. Whereas, this method is time-consuming and least cost-effective. In recent years, AI technology has aroused much attention due to its great success in antibody engineering to create antibodies with multiple specificities, greater affinity, and fewer side effects.
Creative Biolabs is a leading service provider that focuses on antibody engineering for research, diagnostic, and therapeutic use. Our service portfolio includes antibody affinity maturation, antibody stability improvement, scFv/Fab construction, and other antibody specialization and modification services. Based on our AI-powered antibody drug discovery platform, our scientists interrogate and predict antigen-specificity from a massively diverse sequence space to identify globally optimized antibody variants, resulting in thousands of highly-optimized lead candidates. We update the latest data to train our AI model and modify the parameter to train our bespoke algorithm. The submitted antibody sequences maximize the antibodies’ therapeutic potential while minimizing safety and manufacturing risks.
Fig.2 AI-based antibody engineering services.
Creative Biolabs is dedicated to exploring novel and innovative AI-based antibody engineering services to bolster antibody quality and manufacturability. If you are interested in our services, please contact us for more details.
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